By Taotao Zou
This thesis makes a speciality of the improvement of gold- and non-classical platinum-based anti-cancer brokers that show distinctively diversified anti-cancer mechanisms in comparison to the widely used cisplatin. those steel complexes include N-heterocyclic carbene (NHC) ligands that are in a position to shape powerful M-C(NHC) bonds, conferring excessive balance and favorable lipophilicity, reactivity and binding specificity of steel complexes on biomolecules. the writer demonstrates major advances made in anti-cancer gold(III), gold(I) and platinum(II) complexes. specified chemical synthesis, in vitro and/or in vivo anti-cancer actions are in actual fact offered together with: (i) a category of Au(III) complexes containing a hugely fluorescent N^N^N ligand and NHC ligand that concurrently act as fluorescent thiol “switch-on” probes and anti-cancer brokers; (ii) a dinuclear gold(I) advanced with a combined diphosphine and bis(NHC) ligand showing favorable balance and displaying major inhibition of tumor development in self sustaining mice types with out observable unwanted effects; and (iii) a panel of sturdy luminescent cyclometalated platinum(II) complexes displaying excessive specificity to localize to the endoplasmic reticulum (ER) area, inducing ER tension and mobile apoptosis. those works spotlight the medical capability that gold and platinum complexes supply for melanoma treatment.
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Extra info for Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II): Thiol “Switch-on” Fluorescent Probes, Thioredoxin Reductase Inhibitors ... Reticulum Targeting Agents (Springer Theses)
Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II): Thiol “Switch-on” Fluorescent Probes, Thioredoxin Reductase Inhibitors ... Reticulum Targeting Agents (Springer Theses) by Taotao Zou