By Kun Cheng,Ram I. Mahato

ISBN-10: 1119976863

ISBN-13: 9781119976868

RNA interference (RNAi) is a technique in dwelling cells wherein small double stranded RNA interferes with the expression of particular genes with complementary nucleotide series. Like many nucleic acid-based treatments, RNAi has nice power in treating a number of life-threatening illnesses. notwithstanding, the terrible balance and mobile uptake of RNAi molecules stay enormous boundaries to their effective supply that is paramount to a profitable treatment. This publication presents a complete advent to RNAi supply, then is going directly to talk about assorted supply suggestions, and concludes with present functions in a variety of ailments. It covers:

  • Mechanisms, boundaries, and research of RNAi Delivery
  • Nonclinical security exams and scientific Pharmacokinetics: A Regulatory Perspective
  • Bioconjugation of siRNA for website Specifi c Delivery
  • Nanoscale supply structures for RNAi
  • Environmentally-Responsive supply platforms for RNAi
  • Light-sensitive RNAi
  • Viral-Mediated supply of shRNA and miRNA
  • RNAi purposes in melanoma remedy, Liver ailments, Hepatitis B, and Ocular Disease
  • miRNA as healing brokers and targets

Advanced supply and healing purposes of RNAi combines the basic elements of constructing RNAi therapeutics from bench to sanatorium, and is useful for researchers engaged on RNAi, drug discovery and supply, biomedical engineering, biomaterials, molecular biology, and biotechnology.

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Advanced Delivery and Therapeutic Applications of RNAi by Kun Cheng,Ram I. Mahato

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